The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

    Gerard Gormley, Elizabeth Stoner, Reginald C. Bruskewitz, Julianne Imperato-McGinley, PH Walsh, Joseph R. McConnell, Gerald L. Andriole, J. Christoph Geller, Bruce Bracken, Joyce S. Tenover
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    TLDR Finasteride effectively treats BPH but may increase sexual dysfunction risk.
    The study evaluated the effect of finasteride on men with benign prostatic hyperplasia (BPH). Finasteride inhibits the enzyme 5a-reductase, which prevents the conversion of testosterone to dihydrotestosterone, the androgen responsible for prostatic growth and enlargement. The study found that men treated with 5 mg of finasteride per day had a significant decrease in urinary symptoms, an increase in urinary flow, and a decrease in prostatic volume, but at a slightly increased risk of sexual dysfunction. The study concluded that finasteride is an effective treatment for BPH.
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