The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

November 1990 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

Elizabeth Stoner

finasteride 5α-reductase inhibitor dihydrotestosterone DHT Propecia

TLDR Finasteride effectively treats BPH, but needs more trials to understand potential.

The paper discusses the clinical development of finasteride, a 5α-reductase inhibitor used to treat benign prostatic hyperplasia (BPH). Studies showed that finasteride significantly decreased the level of circulating dihydrotestosterone (DHT) in normal volunteers and suppressed intraprostatic DHT levels in BPH patients. Prostate volume decreased by a mean of 18% after 12 weeks of treatment and continued to shrink throughout the initial 6 months of therapy. The maximum urinary flow rate increased by approximately 3 ml/s in the drug-treated group. The paper concludes that finasteride is effective in treating BPH, but more extensive clinical trials are needed to fully understand its therapeutic potential.

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community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community My Testosterone results before and after Finasteride

in Update 146 upvotes 3 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 339 upvotes 1 year ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 160 upvotes 1 year ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

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The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

Related Community Posts Join

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

community Proof that finasteride messes with neurosteroids

community My Testosterone results before and after Finasteride

community One year anti androgen update CROWN

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

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