Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

April 1990 in “ The Journal of Clinical Endocrinology and Metabolism ”

Glenn J. Gormley, Elizabeth Stoner, Roger S. Rittmaster, Hall Gregg, David R. Thompson, Kenneth C. Lasseter, Peter H. Vlasses, Evan A. Stein

finasteride 5α-reductase inhibitor DHT androgen-dependent conditions benign prostatic hyperplasia male pattern baldness testosterone androstenedione Propecia 5-alpha-reductase inhibitor dihydrotestosterone BPH androgenic alopecia

TLDR Finasteride safely lowers DHT levels without affecting testosterone.

Finasteride is a drug that inhibits 5α-reductase and reduces DHT levels in male volunteers. It does not affect testosterone and androstenedione levels. It is a potential treatment for androgen-dependent conditions like benign prostatic hyperplasia and male pattern baldness. The study found that finasteride is a safe and effective inhibitor of 5α-reductase in men, leading to a significant decrease in serum DHT levels. No adverse effects were reported during the study.

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research Clinical Usefulness of Plasma Androstanediol Glucuronide Measurements in Women with Idiopathic Hirsutism

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community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 104 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 445 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 18->24 six years of Fin and Minox…. I guess we can’t all be winners 😭

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A user named "EgyptStar81" who has been dealing with hair loss since age 15 due to genetics, chemotherapy and finasteride/minoxidil treatment. Possible solutions such as dutasteride, oral minoxidil, hair transplants and extensions were suggested.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 11 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community The theory that explains everything - First Evidence of Hair regrow attributed to upregulating 3aHSD

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Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

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