5α-Reductase Inhibitors and Prostatic Disease

    August 1994 in “ Clinical endocrinology ”
    Fritz H. Schröder
    Studysummary This article reviews the effects of 5 alpha-reductase inhibitors for treating conditions like male pattern baldness and benign prostatic hyperplasia, noting significant DHT reduction but reports no new clinical results.
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    Research cited in this study 7

    1. LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5 Alpha-Reductase Type 1 Proceedings of the National Academy of Sciences of the United States of America · 1993
    2. Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor Toxicology and Applied Pharmacology · 1993
    3. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993
    4. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992
    5. Greater Conversion of Testosterone to 5α-Dihydrotestosterone, Reflecting Increased Peripheral 5α-Reductase Activity in Nude Mice Treated with High Doses of Cyclosporine A Journal of Steroid Biochemistry · 1990
    6. External Genitalia Abnormalities in Male Rats Exposed In Utero to Finasteride, a 5α-Reductase Inhibitor Teratology · 1990
    7. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985

    Related research 10

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    3. Effective Treatment of Female Androgenic Alopecia with Dutasteride PubMed · 2005
    4. 5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia International Journal of Cosmetic Surgery and Aesthetic Dermatology · 2001
    5. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    6. Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia Expert Opinion on Investigational Drugs · 1999
    7. Finasteride for Androgenetic Alopecia NEJM Journal Watch · 1998
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    9. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    10. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994