Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients After Finasteride Treatment for a Year

August 2021 in “ Journal of The American Academy of Dermatology ”

Ji-Hoon Lim, Yura Lee, Eunju Im, Haksoon Kim, Jeongae Lee, Han Bin Oh, Ki-Jung Paeng, Min H. Kang, Soon Young Kwon, Woo-Young Sim, Bark-Lynn Lew

finasteride male pattern baldness metabolomics steroid signatures 5-alpha reductase dihydrotestosterone testosterone Propecia MPB DHT T

TLDR Finasteride treatment changes hormone levels in male pattern baldness patients.

The study investigated the effects of finasteride treatment on male pattern baldness (MPB) by analyzing metabolomics and steroid signatures in the urine of patients over a year. Finasteride, which inhibits the 5-alpha reductase enzyme and blocks dihydrotestosterone (DHT) production, was found to impact the levels of DHT and testosterone (T) in patients. The research aimed to provide a comprehensive understanding of the metabolic changes associated with finasteride treatment in MPB patients.

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community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

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in Finasteride/Dutasteride 331 upvotes 10 months ago

A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community Derm prescribed ketoconazole 2% shampoo, claiming my case “is not bad enough yet” for fin. Second opinion?

in Treatment 85 upvotes 1 year ago

A user was prescribed ketoconazole shampoo by their dermatologist for early-stage hair loss, but is unsure if this is the right treatment. Most commenters suggest seeking a second opinion or starting finasteride treatment immediately, while a few caution about potential side effects.

community Is this progess? Somedays I’m not sure.

in Is this regrowth? 57 upvotes 1 year ago

The user is seeking confirmation of progress in their hair regrowth journey while using oral finasteride and topical minoxidil. They also mention experiencing shedding and dandruff after switching from liquid minoxidil to foam. Some users suggest considering a hair transplant.

community Finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.

in Research/Science 531 upvotes 9 months ago

The conversation discusses the potential benefits of finasteride (Fin) for lowering cholesterol and reducing cardiovascular disease risk, with users sharing personal experiences and opinions on the medication's effects on health and hair loss. Some users report positive changes in cholesterol levels after taking finasteride, while others are skeptical or joke about its effects.

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research Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments

58 citations, September 2012 in “Dermatologic Clinics”

Male pattern hair loss caused by follicular miniaturization; early diagnosis and treatment can reduce psychological burden.