Greater Conversion of Testosterone to 5α-Dihydrotestosterone, Reflecting Increased Peripheral 5α-Reductase Activity in Nude Mice Treated with High Doses of Cyclosporine A

August 1990 in “ Journal of Steroid Biochemistry ”

Philippe Boudou, Jean Fiet, Patrick Vexiau, Jean‐Marie Villette, Noah Hardy, C Dreux

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Research cited in this study

3 / 3 results

research Does Cyclosporin A Influence Sex Hormone Level?

20 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

Cyclosporin A does not change sex hormone levels.

research Cyclosporin A Stimulates Hair Growth in Nude Mice

55 citations , June 1987 in “PubMed”

Cyclosporin A significantly increases hair growth in certain areas of mice.

research Peripheral Androgens And The Role Of Androstanediol Glucuronide

57 citations , May 1986 in “Clinics in endocrinology and metabolism”

Androstanediol glucuronide is a reliable marker for hirsutism in women.

Related Research

2 / 2 results

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.

research Bioactive and Peripheral Androgens in Prepubertal Simple Hypertrichosis

11 citations , September 1990 in “Clinical Endocrinology”

Prepubertal simple hypertrichosis was characterized by excessive vellus hair growth in children without other endocrine disorders, and its cause was unknown. A study involving 16 girls with this condition and 12 age-matched controls found that testosterone, androstenedione, and dehydroepiandrosterone sulphate levels were similar between the groups, indicating no increased androgen secretion. Additionally, sex hormone binding globulin, free testosterone, and the testosterone/SHBG ratio were normal, suggesting typical testosterone bioavailability. However, dihydrotestosterone (DHT) levels were significantly higher in the affected girls compared to controls, while 3α-androstanediol and its glucuronide were similar. The elevated DHT levels' clinical and biochemical significance required further investigation.