TLDR Girls with prepubertal simple hypertrichosis have higher dihydrotestosterone (DHT) levels.
The study investigated prepubertal simple hypertrichosis, characterized by excessive vellus hair growth in children, by examining 16 girls with the condition and 12 age-matched controls. The research aimed to determine if this condition was linked to abnormal androgen levels. The study found that testosterone, androstenedione, and dehydroepiandrosterone sulphate levels were similar between the hypertrichosis group and controls, indicating no increased glandular androgen secretion. However, dihydrotestosterone (DHT) levels were significantly higher in the hypertrichosis group, while 3α-androstanediol and its glucuronide were comparable to controls. The elevated DHT levels, without corresponding increases in other metabolites, suggested a unique biochemical profile in these patients, warranting further investigation into the clinical significance of high DHT levels in prepubertal simple hypertrichosis.
57 citations
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November 1987 in “Pediatric Dermatology” Children's hair grows in different types from before birth through puberty, with growth rates and characteristics varying by age, sex, and race.
66 citations
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October 1987 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Measuring androstanediol glucuronide in blood is useful for assessing and tracking treatment in women with excessive hair growth.
22 citations
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May 1986 in “Clinics in endocrinology and metabolism” Certain finger length ratios and body hair patterns may predict side effects from birth control pills in women.
179 citations
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May 1982 in “The Journal of clinical investigation/The journal of clinical investigation” High levels of 3 alpha-diol glucuronide in the blood are a marker of increased androgen action in women with excessive hair growth of unknown cause.
157 citations
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April 1994 in “Clinical endocrinology” Androgens can cause hair growth in some areas and hair loss on the scalp.
1 citations
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February 2017 in “Journal of gynecology and womens health” The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.
46 citations
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May 1986 in “Seminars in Reproductive Medicine” Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.
67 citations
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September 2008 in “Dermatologic therapy” Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.
271 citations
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December 2005 in “New England journal of medicine/The New England journal of medicine” The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.
