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GlossaryCyclosporine (CsA)

immunosuppressive drug used to prevent organ rejection and treat autoimmune diseases

Cyclosporine, also known as cyclosporin A or CsA, is an immunosuppressive drug primarily used to prevent organ transplant rejection and to treat certain autoimmune conditions. It works by inhibiting the activity of T-cells, a type of white blood cell involved in the immune response. In dermatology, cyclosporine has been explored for its potential to treat severe cases of alopecia areata, a condition characterized by sudden hair loss.

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research Integrating Multi-Omics Analyses of Nonomuraea Dietziae to Reveal the Role of Soybean Oil in [(4′-OH)MeLeu]4-CsA Overproduction

1 citations, July 2017 in “Microbial Cell Factories”

Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.

research CsA-Induced Hypertrichosis Might Be Caused in Part by Inhibition of TGF-β2 Expression in Dermal Papilla Cells

November 2022 in “Journal of Investigative Dermatology”

The medicine Cyclosporin A might cause excessive hair growth by reducing a protein that controls hair growth.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

124 citations, August 1994 in “Journal of Investigative Dermatology”

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

research Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

68 citations, May 2018 in “PLOS Biology”

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

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community Forgotten 'Total Revival' Stack

in Research/Science 42 upvotes 6 days ago

Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

community I will never more buy any hairloss traitements in public pharmacy

in Minoxidil 420 upvotes 6 months ago

A user was embarrassed by a pharmacist's loud mention of "minoxidil" for hair loss, sparking a discussion on the stigma and unprofessionalism. Users suggested online purchases or different pharmacies for privacy and reassured that most people don't notice others' purchases.

community Huge Group Buy is Now Live with New and Existing Treatments

in Product 146 upvotes 1 year ago

A group buy for hair loss treatments including Harmine 19a, TM5614, Abiraterone Acetate, and others. A compound, BMS-202, that can potentially reverse gray hair is also mentioned.