FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects

June 1996 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

D. Giudici, G. Briatico, C. Cominato, T. Zaccheo, Catherine Iehlé, Marcella Nesi, A. Panzeri, E. Di Salle

FCE 28260 5α-reductase inhibitor finasteride in vitro in vivo IC50 human recombinant 5αR type 1 human recombinant 5αR type 2 ventral prostate growth prostatic DHT concentrations benign prostatic hyperplasia androgenic alopecia Propecia DHT BPH

TLDR FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

In the 1996 study, FCE 28260 was found to be a potent inhibitor of 5α-reductase, more effective than finasteride, a reference compound, in both in vitro and in vivo settings. FCE 28260 demonstrated lower IC50 values, indicating stronger inhibitory effects on the enzyme, and was more potent in inhibiting human recombinant 5αR type 1 and type 2 isozymes. In vivo, it reduced ventral prostate growth in castrated rats more effectively than finasteride and showed a longer-lasting reduction in prostatic DHT concentrations. The study, which involved six to seven rats per group for each dosing experiment, concluded that FCE 28260 could be a more effective treatment for conditions like benign prostatic hyperplasia and potentially androgenic alopecia due to its stronger and longer-lasting inhibition of 5αR.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research 5α-Reductase Inhibitors and Prostatic Disease

21 citations, August 1994 in “Clinical endocrinology”

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

research Finasteride

86 citations, July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations, October 1992 in “The New England Journal of Medicine”

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations, August 1985 in “Endocrinology”

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Related Community Posts Join

2 / 2 results

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 3 months ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community So does oral minoxidil age your skin or not

in Minoxidil 41 upvotes 8 months ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

Related Research

2 / 2 results

research FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects

17 citations, June 1996 in “The Journal of Steroid Biochemistry and Molecular Biology”

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.