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    Glossary IC50

    concentration needed to inhibit a biological process by 50%

    IC50, or Half Maximal Inhibitory Concentration, is a measure used in pharmacology to indicate how much of a substance (like a drug or inhibitor) is needed to inhibit a biological process or the activity of a target (such as an enzyme or cell receptor) by 50%. This value helps researchers understand the potency of a compound, with a lower IC50 indicating a more potent inhibitor.

    Research 10 of 787

    1. 2-Substituted 4-(Thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2002 · 111 citations
    2. In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5α-reductase inhibitors The Journal of Steroid Biochemistry and Molecular Biology · 2008 · 27 citations
    3. Biphasic Effect of 1,25-Dihydroxyvitamin D3 on Human Hair Follicle Growth and Hair Fiber Production in Whole-Organ Cultures 1994 · 27 citations
    4. Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase Journal of Medicinal Chemistry · 2001 · 27 citations
    5. Molecular Interactions of New Pregnenedione Derivatives Chemical and Pharmaceutical Bulletin · 2003 · 20 citations
    6. Novel inhibitors of 5α-reductase Expert Opinion on Therapeutic Patents · 2002 · 20 citations
    7. Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors Steroids · 2010 · 19 citations
    8. Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor Bioorganic & Medicinal Chemistry Letters · 2010 · 18 citations
    9. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    10. Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach European journal of medicinal chemistry · 2012 · 17 citations
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    Community 3

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    3. FCE 28260: A Forgotten 5α-Reductase Inhibitor Community · 22 Aug 2024

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