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    Glossary CHIR99021

    small molecule inhibits GSK-3, aiding stem cell research

    CHIR99021 is a small molecule inhibitor that specifically targets glycogen synthase kinase 3 (GSK-3). By inhibiting GSK-3, CHIR99021 can promote the self-renewal and pluripotency of stem cells, making it a valuable tool in stem cell research and regenerative medicine.

    Research 10 of 84

    1. Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin Biochemical and Biophysical Research Communications · 2019 · 40 citations
    2. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    3. In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides) Frontiers in physiology · 2022 · 6 citations
    4. In ovo injection of CHIR-99021 promotes feather follicles development via activating Wnt/β-catenin signaling pathway during chick embryonic period Poultry Science · 2022 · 15 citations
    5. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    6. Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells PLOS ONE · 2016 · 21 citations
    7. Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules International Journal of Molecular Sciences · 2022 · 3 citations
    8. Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss International Journal of Molecular Sciences · 2022 · 2 citations
    9. NIR‐Responsive Multifunctional Artificial Skin for Regenerative Wound Healing Advanced Functional Materials · 2024 · 1 citations
    10. TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network Advanced Science · 2026
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