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GlossaryCHIR99021

small molecule inhibits GSK-3, aiding stem cell research

CHIR99021 is a small molecule inhibitor that specifically targets glycogen synthase kinase 3 (GSK-3). By inhibiting GSK-3, CHIR99021 can promote the self-renewal and pluripotency of stem cells, making it a valuable tool in stem cell research and regenerative medicine.

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research Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin

40 citations , June 2019 in “Biochemical and Biophysical Research Communications”

CHIR99021 helps create human skin with hair follicles, offering hope for hair loss treatments.

HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

research HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

7 citations , March 2021 in “Molecular Medicine Reports”

A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations , May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells

21 citations , December 2016 in “PLOS ONE”

Scientists made skin stem cells from other human cells with over 97% efficiency, which could help treat skin conditions.

research Direct Reprogramming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules

3 citations , April 2022 in “International Journal of Molecular Sciences”

Scientists turned mouse skin cells into hair-inducing cells using chemicals, which could help treat hair loss.

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community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.