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GlossaryCHIR99021

small molecule inhibits GSK-3, aiding stem cell research

CHIR99021 is a small molecule inhibitor that specifically targets glycogen synthase kinase 3 (GSK-3). By inhibiting GSK-3, CHIR99021 can promote the self-renewal and pluripotency of stem cells, making it a valuable tool in stem cell research and regenerative medicine.

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HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

research HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

7 citations, March 2021 in “Molecular Medicine Reports”

A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations, May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells

21 citations, December 2016 in “PLOS ONE”

Scientists made skin stem cells from other human cells with over 97% efficiency, which could help treat skin conditions.

research Direct Reprogramming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules

3 citations, April 2022 in “International Journal of Molecular Sciences”

Scientists turned mouse skin cells into hair-inducing cells using chemicals, which could help treat hair loss.

research Changes in the Expression of Smooth Muscle Cell-Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss

2 citations, June 2022 in “International Journal of Molecular Sciences”

Lower levels of certain genes in hair cells improve hair loss treatment outcomes.

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community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.