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    Glossary CHIR99021

    small molecule inhibits GSK-3, aiding stem cell research

    CHIR99021 is a small molecule inhibitor that specifically targets glycogen synthase kinase 3 (GSK-3). By inhibiting GSK-3, CHIR99021 can promote the self-renewal and pluripotency of stem cells, making it a valuable tool in stem cell research and regenerative medicine.

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    Research 30 of 84

    1. Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin Biochemical and Biophysical Research Communications · 2019 · 40 citations
    2. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    3. In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides) Frontiers in physiology · 2022 · 6 citations
    4. In ovo injection of CHIR-99021 promotes feather follicles development via activating Wnt/β-catenin signaling pathway during chick embryonic period Poultry Science · 2022 · 15 citations
    5. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    6. Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells PLOS ONE · 2016 · 21 citations
    7. Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules International Journal of Molecular Sciences · 2022 · 3 citations
    8. Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss International Journal of Molecular Sciences · 2022 · 2 citations
    9. NIR‐Responsive Multifunctional Artificial Skin for Regenerative Wound Healing Advanced Functional Materials · 2024 · 1 citations
    10. TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network Advanced Science · 2026
    11. 231 Novel protocol for the invitro maintenance and expansion of adult epidermal LGR5+ stem cells Reproduction Fertility and Development · 2019
    12. Tissue engineering of human hair follicles using a biomimetic developmental approach Nature Communications · 2018 · 184 citations
    13. Hierarchical patterning modes orchestrate hair follicle morphogenesis PLoS Biology · 2017 · 149 citations
    14. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    15. Feather arrays are patterned by interacting signalling and cell density waves PLoS Biology · 2019 · 133 citations
    16. Small molecules and small molecule drugs in regenerative medicine Drug Discovery Today · 2013 · 51 citations
    17. Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal? Stem Cells Translational Medicine · 2019 · 29 citations
    18. Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate Genes · 2019 · 28 citations
    19. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    20. Hair follicle germs containing vascular endothelial cells for hair regenerative medicine Scientific Reports · 2021 · 23 citations
    21. Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives Stem Cells International · 2019 · 17 citations
    22. ROR2 regulates self-renewal and maintenance of hair follicle stem cells Nature Communications · 2022 · 16 citations
    23. The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size Nature Communications · 2025 · 1 citations
    24. Hair Dermal papilla maintain its hair inducing characteristics via autocrine exosomal miR-23a-3p 2025
    25. KIF18B is a cell-type specific regulator of spindle orientation in the epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2021
    26. Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment Inflammation and Regeneration · 2020 · 17 citations
    27. Pathophysiological mechanisms of hair follicle regeneration and potential therapeutic strategies Stem Cell Research & Therapy · 2025
    28. 676 Wnt and SHH interact to determine hair follicle dermal condensate fate Journal of Investigative Dermatology · 2024
    29. Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture Cell · 2018 · 249 citations
    30. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018 · 169 citations