In Vivo and In Vitro Effect of Novel 4,16-Pregnadiene-6,20-Dione Derivatives as 5α-Reductase Inhibitors

July 2008 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

Eugene Bratoeff, Marisa Cabeza, Victor Pérez-Ornelas, Sergio Recillas‐Morales, Ivonne Heuze

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research New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects

45 citations , February 2005 in “Steroids”

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research Novel Inhibitors of 5α-Reductase

20 citations , February 2002 in “Expert Opinion on Therapeutic Patents”

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations , August 1985 in “Endocrinology”

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.