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GlossaryCD200 receptor

protein on immune cells that regulates immune response

The CD200 receptor (CD200R) is a protein found on the surface of certain immune cells, such as macrophages and dendritic cells. It plays a crucial role in regulating the immune response by interacting with its ligand, CD200, to send inhibitory signals that help prevent excessive inflammation and autoimmunity. This interaction is important in maintaining immune tolerance and has implications in conditions like alopecia, where immune regulation is disrupted.

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research ARQ-234: A High Affinity CD200-Fc Fusion Protein for the Treatment of Atopic Dermatitis

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

ARQ-234, a protein designed to treat atopic dermatitis, shows increased effectiveness in early testing.

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

research The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

32 citations , January 2012 in “Clinical & Developmental Immunology”

Targeting CD200 could be a new treatment for rheumatoid arthritis.

research Behavior of Human Foreskin Keratinocytes Expressing a Hair Follicle Stem Cell Marker CD200

12 citations , November 2007 in “Journal of Investigative Dermatology”

CD200 is not a reliable marker for identifying stem cells in all skin types.

research Frontal Fibrosing Alopecia: An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?

8 citations , July 2020 in “Clinical, cosmetic and investigational dermatology”

Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

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community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 1 week ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.