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GlossaryCD200 receptor

protein on immune cells that regulates immune response

The CD200 receptor (CD200R) is a protein found on the surface of certain immune cells, such as macrophages and dendritic cells. It plays a crucial role in regulating the immune response by interacting with its ligand, CD200, to send inhibitory signals that help prevent excessive inflammation and autoimmunity. This interaction is important in maintaining immune tolerance and has implications in conditions like alopecia, where immune regulation is disrupted.

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research ARQ-234: A High Affinity CD200-Fc Fusion Protein for the Treatment of Atopic Dermatitis

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

ARQ-234, a protein designed to treat atopic dermatitis, shows increased effectiveness in early testing.

research Behavior of Human Foreskin Keratinocytes Expressing a Hair Follicle Stem Cell Marker CD200

12 citations , November 2007 in “Journal of Investigative Dermatology”

CD200 is not a reliable marker for identifying stem cells in all skin types.

Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

research Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

31 citations , February 2014 in “Inflammation Research”

Lower CD200R1 on certain immune cells is linked to more severe rheumatoid arthritis and immune imbalance.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Epidermal Stem Cells: Practical Perspectives and Potential Uses

62 citations , April 2009 in “British Journal of Dermatology”

Epidermal stem cells could lead to new treatments for skin and hair disorders.

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community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 3 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 1 month ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.