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Did you mean CD1a+ Langerhans cells?

Glossary CD1a+ Langerhans cells

immune cells in skin presenting antigens to T-cells

CD1a+ Langerhans cells are a type of immune cell found in the skin and mucous membranes. They play a crucial role in the body's defense system by capturing and presenting antigens to T-cells, which helps initiate an immune response. The "CD1a+" designation refers to a specific protein marker on their surface that is used to identify them.

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Research

5 / 213 results

research The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells that Repopulate Epidermis After UVB Exposure

99 citations , April 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that human hair follicles serve as a crucial reservoir for Langerhans cells, which repopulate the epidermis depleted by ultraviolet B exposure.

research P130 The densities of T cells, Langerhans cells, and natural killer cells in uninvolved skin of patients with acne vulgaris

September 1997 in “Journal of the European Academy of Dermatology and Venereology”

People with acne have more CD4+ immune cells in their skin than healthy people.

research 40nm, but not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells after Transcutaneous Application on Human Skin

323 citations , April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that 40 nm nanoparticles can effectively penetrate into hair follicles and epidermal Langerhans cells in human skin samples, potentially enabling efficient transcutaneous vaccine delivery.

research Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege

March 2024 in “International Journal of Cosmetic Science”

This study observed that dandruff-affected scalp skin has increased T-cell infiltration in the epidermis and a reduction in the hair follicle's physiological immune privilege, particularly in the suprabulbar outer root sheath area, indicating a distinct immune microenvironment compared to healthy scalp.

research 035 Expansion of bacterial phosphatidylglycerol reactive CD4+ T cells in atopic dermatitis

April 2021 in “Journal of Investigative Dermatology”

This study found that CD1a-restricted CD4+ T cells responsive to lysyl-phosphatidylglycerol were more frequent in the blood of atopic dermatitis patients, suggesting a potential role in the disease's Th2-mediated pathology.

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