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GlossaryCD200

protein that helps regulate immune response in hair follicles

CD200 is a protein found on the surface of certain cells, including hair follicle cells, and plays a role in immune regulation. It helps to prevent the immune system from attacking the body's own tissues, which is particularly relevant in conditions like alopecia, where the immune system mistakenly targets hair follicles.

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Research

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Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

research Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

31 citations, February 2014 in “Inflammation Research”

Lower CD200R1 on certain immune cells is linked to more severe rheumatoid arthritis and immune imbalance.

research Th1/Th2 Peripheral Blood Balance and CD200 Expression in Patients with Active Severe Alopecia Areata

12 citations, April 2017 in “Experimental and Therapeutic Medicine”

Patients with severe active alopecia areata have lower CD200 expression and an imbalance in their immune system.

Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

research Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

11 citations, September 2019 in “Dermatologic Surgery”

A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.

research ARQ-234: A High Affinity CD200-Fc Fusion Protein for the Treatment of Atopic Dermatitis

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

ARQ-234, a protein designed to treat atopic dermatitis, shows increased effectiveness in early testing.

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community Fin 3xweek and dermarolling since end of April – October

in Progress Pictures 124 upvotes 2 years ago

A user's progress with finasteride and dermarolling to regrow their hairline, with other users noting the improvement.

community April 15th- August 8th progress. Fin 1mg daily, Min 1-2x a day, keto twice a week and microneedling sometimes

in Progress Pictures 119 upvotes 2 years ago

Treating hair loss with finasteride, minoxidil, keto diet, and microneedling; the user has seen good results but wants to focus more on their temples; another user suggested using an exfoliating comb while shampooing.

community Donald Glover’s (aka Childish Gambino) seamless hair transplant results

in Transplants 1 year ago

Donald Glover's (aka Childish Gambino) hair transplant results, which appear to be moderate with around 1000 grafts. Various users discuss the previous and current appearance of his hairline and speculate that he may have used medications like Minoxidil or finasteride to stabilize before getting a transplant.

community Final Result. 1 Year post Hair Transplant

in Transplants 298 upvotes 2 years ago

A user's experience with a hair transplant procedure and the resulting appearance of their hairline, which included some micro irregularities to make it look natural. Other users asked questions related to cost and safety of similar procedures at different clinics.

community Finally decided to buzz my head after experiencing hair loss since I was 17 (23 now). I think it looks decent, swipe to see what I was rocking before during the pandemic. Who knows maybe I’ll hop on fin but as someone who struggles with chronic fatigue and low test I’m hesitant.

in Shaved/buzzed 326 upvotes 2 years ago

A user's decision to shave their head after experiencing hair loss since the age of 17, and discussion around the potential use of Fin for treating hair loss.

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