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Glossary CD90

cell surface protein involved in cell adhesion and signaling

CD90, also known as Thy-1, is a cell surface protein that plays a role in cell-cell and cell-matrix interactions. It is commonly found on stem cells, neurons, and fibroblasts, and is involved in processes such as cell adhesion, migration, and differentiation. In the context of hair biology, CD90 is often studied for its role in the regulation of hair follicle stem cells and their ability to regenerate hair.

Research

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research Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90

47 citations , August 2016 in “American Journal Of Pathology”

This study reports that in systemic sclerosis, CD34+ dermal fibroblasts transition to CD34−, podoplanin+, and CD90+ fibroblasts across the dermis, suggesting a role in unchecked fibrosis.

research Defining Skin Fibroblastic Cell Types Beyond CD90

31 citations , October 2018 in “Frontiers in Cell and Developmental Biology”

The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

15 citations , September 2009 in “European Journal of Histochemistry”

This study found that CD90+ cells, resembling mesenchymal stem cells, are abundantly present in the lower part of anagen hair follicles in dogs.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

6 citations , September 2009 in “European journal of histochemistry”

This study found that CD90+ stem cells with fibroblast-like morphology are present in the lower part of the anagen hair follicle in dogs.

research The GPI-Anchored Protein Thy-1/CD90 Promotes Wound Healing upon Injury to the Skin by Enhancing Skin Perfusion

4 citations , October 2022 in “International Journal of Molecular Sciences”

In this study, Thy-1 was observed to play a critical role in wound healing in mice, particularly influencing vascular dynamics and blood perfusion during the healing process.

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