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GlossaryCD44

cell surface protein involved in cell communication and migration

CD44 is a cell surface protein that plays a crucial role in cell communication, migration, and adhesion. It is involved in various biological processes, including wound healing and immune responses, and is also a marker used in cancer research to identify and study cancer stem cells.

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research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

135 citations, December 2006 in “PLoS Medicine”

Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.

research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability

28 citations, January 2013 in “Stem cells”

Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.

research CD44 Expression in Alopecia Areata and Androgenetic Alopecia

5 citations, June 1994 in “Journal of Cutaneous Pathology”

No CD44 in alopecia areata, present in normal and androgenetic alopecia.

research Identification of Two Distinct Stem Cell Clusters, Lrig1-Derived and Wnt/CD44-Dependent, in Corneal Epithelium

April 2018 in “Journal of Investigative Dermatology”

The conclusion is that the cornea has two types of stem cells, with Lrig1+ cells being key for renewal in aging corneas, independent of CD44.

research WNT10A Promotes an Invasive and Self-Renewing Phenotype in Esophageal Squamous Cell Carcinoma

55 citations, March 2015 in “Carcinogenesis”

WNT10A helps esophageal cancer cells spread and keep renewing themselves.

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community The Cure isn't 5 years away; it's already here.

in Research/Science 996 upvotes 3 weeks ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.