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GlossaryCD44

cell surface protein involved in cell communication and migration

CD44 is a cell surface protein that plays a crucial role in cell communication, migration, and adhesion. It is involved in various biological processes, including wound healing and immune responses, and is also a marker used in cancer research to identify and study cancer stem cells.

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

135 citations , December 2006 in “PLoS Medicine”

Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.

research Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata

77 citations , June 2002 in “Journal of Investigative Dermatology”

CD44 variant changes start alopecia areata, but don't maintain it.

research Anti-CD44-Mediated Blockade of Leukocyte Migration in Skin-Associated Immune Diseases

30 citations , April 2007 in “Journal of Leukocyte Biology”

Blocking CD44 can reduce leukocyte migration in autoimmune skin diseases.

research Hyaluronate Accumulation and Decreased CD44 Expression in Perifollicular Solitary Cutaneous Myxoma

9 citations , January 2002 in “Dermatology”

Reduced CD44 expression may cause abnormal hyaluronate buildup in cutaneous myxoma.

research CD44 Signaling in Skin Wound Healing and Regeneration

8 citations , August 2025 in “Journal of Translational Medicine”

CD44 signaling can help heal wounds without scars.

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community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.