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GlossaryCXCR4

receptor protein involved in immune cell movement and cancer

CXCR4, also known as C-X-C chemokine receptor type 4 or CD184, is a protein found on the surface of certain cells that plays a crucial role in the immune system. It acts as a receptor for a molecule called CXCL12, which helps guide the movement of cells, including immune cells, to sites where they are needed, such as areas of inflammation or injury. This receptor is also involved in the development and progression of various diseases, including cancer and HIV, making it a significant target for medical research and therapeutic interventions.

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research CXCL12 Inhibits Hair Growth Through CXCR4

April 2022 in “Biomedicine & Pharmacotherapy”

CXCL12 protein slows down hair growth through its receptor CXCR4. Blocking this can potentially increase hair growth.

research Role of Sdf1-Cxcr4 Signaling in Mouse Appendage Regeneration

April 2016 in “Journal of Investigative Dermatology”

Mice without the p21 gene can fully regenerate injured ears due to reduced Sdf1 increase and leukocyte recruitment, suggesting new ways to induce tissue regeneration in mammals.

research The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

57 citations, April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

research The Polygenic Architecture Of Hidradenitis Suppurativa Reveals Signaling Mechanisms That Implicate Epithelial Remodeling

July 2025

Blocking CXCR4 may help treat hidradenitis suppurativa.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations, December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

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