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    Glossary CXCR4

    receptor protein involved in immune cell movement and cancer

    CXCR4, also known as C-X-C chemokine receptor type 4 or CD184, is a protein found on the surface of certain cells that plays a crucial role in the immune system. It acts as a receptor for a molecule called CXCL12, which helps guide the movement of cells, including immune cells, to sites where they are needed, such as areas of inflammation or injury. This receptor is also involved in the development and progression of various diseases, including cancer and HIV, making it a significant target for medical research and therapeutic interventions.

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    1. Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways Scientific Reports · 2017 · 44 citations
    2. Plerixafor Engages β-Arrestin-Dependent CXCR4 Signaling to Promote Melanogenesis via β-Catenin-MITF Activation Current Issues in Molecular Biology · 2026
    3. Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation Preprints.org · 2026
    4. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025
    5. CXCL12 inhibits hair growth through CXCR4 Biomedicine & Pharmacotherapy · 2022
    6. 744 Role of Sdf1-Cxcr4 signaling in mouse appendage regeneration Journal of Investigative Dermatology · 2016
    7. PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus Rheumatology · 2019 · 71 citations
    8. Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis Cancer Research · 2008 · 70 citations
    9. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016 · 64 citations
    10. Author response: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis 2019 · 1 citations
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