Search
for

    Glossary CXCR4

    receptor protein involved in immune cell movement and cancer

    CXCR4, also known as C-X-C chemokine receptor type 4 or CD184, is a protein found on the surface of certain cells that plays a crucial role in the immune system. It acts as a receptor for a molecule called CXCL12, which helps guide the movement of cells, including immune cells, to sites where they are needed, such as areas of inflammation or injury. This receptor is also involved in the development and progression of various diseases, including cancer and HIV, making it a significant target for medical research and therapeutic interventions.

    Related Terms

    Sort by

    Research 30 of 704

    1. Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways Scientific Reports · 2017 · 44 citations
    2. Plerixafor Engages β-Arrestin-Dependent CXCR4 Signaling to Promote Melanogenesis via β-Catenin-MITF Activation Current Issues in Molecular Biology · 2026
    3. Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation Preprints.org · 2026
    4. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025
    5. CXCL12 inhibits hair growth through CXCR4 Biomedicine & Pharmacotherapy · 2022
    6. 744 Role of Sdf1-Cxcr4 signaling in mouse appendage regeneration Journal of Investigative Dermatology · 2016
    7. PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus Rheumatology · 2019 · 71 citations
    8. Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis Cancer Research · 2008 · 70 citations
    9. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016 · 64 citations
    10. Author response: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis 2019 · 1 citations
    11. Decision letter: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis 2019
    12. Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice Experimental and Therapeutic Medicine · 2017
    13. Insights into the context-dependent immunological roles of the CXCL12–CXCR4 axis in alopecia Frontiers in Immunology · 2026
    14. The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles Differentiation · 2009 · 57 citations
    15. Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin Stem Cells · 2013 · 43 citations
    16. CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17 The Journal of Experimental Medicine · 2024 · 32 citations
    17. Skin Wound Healing Elsevier eBooks · 2016 · 5 citations
    18. The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling 2025
    19. 線維芽細胞凝集塊形成による幹細胞形成機構の解明 Institutional Repositories DataBase (IRDB) · 2014
    20. 線維芽細胞凝集塊形成による幹細胞形成機構の解明 Institutional Repositories DataBase (IRDB) · 2014
    21. Scarless wound healing: finding the right cells and signals Cell and Tissue Research · 2016 · 132 citations
    22. Type 1 interferon signature in the scalp lesions of alopecia areata British Journal of Dermatology · 2010 · 52 citations
    23. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development 2012 · 48 citations
    24. Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata Annals of Dermatology · 2019 · 17 citations
    25. Antroquinonol Exerts Immunosuppressive Effect on CD8<sup>+</sup> T Cell Proliferation and Activation to Resist Depigmentation Induced by H<sub>2</sub>O<sub>2</sub> Oxidative medicine and cellular longevity · 2017 · 11 citations
    26. Alopecia areata after mogamulizumab treatment JAAD Case Reports · 2021 · 7 citations
    27. Alopecia areata possibly induced by autoimmune reaction in a patient with human T‐cell lymphotropic virus‐1‐associated myelopathy The Journal of Dermatology · 2013 · 6 citations
    28. An occurrence of eosinophilic folliculitis and alopecia associated with a sustained complete response to mogamulizumab in Sézary syndrome: a case report Therapeutic Advances in Hematology · 2024 · 5 citations
    29. Granulocyte colony stimulating factor promotes scarless tissue regeneration Cell Reports · 2024 · 4 citations
    30. Th1 Chemokine CXCL10 and Alopecia Areata: The Possible Target for the Treatment of Alopecia Areata Journal of Clinical & Cellular Immunology · 2016 · 3 citations