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    Glossary CXCL12

    signaling protein involved in immune response and tissue repair

    CXCL12, also known as Stromal cell-derived factor 1 (SDF-1), is a protein that plays a crucial role in the body's immune response and tissue repair. It acts as a signaling molecule, attracting cells to areas where they are needed, such as sites of injury or inflammation. This protein is also important in the development and maintenance of various tissues, including hair follicles, and has been studied for its potential role in conditions like alopecia.

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    1. The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles Differentiation · 2009 · 57 citations
    2. CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17 The Journal of Experimental Medicine · 2024 · 32 citations
    3. Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata Annals of Dermatology · 2019 · 17 citations
    4. Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing Frontiers in Immunology · 2024 · 7 citations
    5. Combination of an engineered <i>Lactococcus lactis</i> expressing CXCL12 with light‐emitting diode yellow light as a treatment for scalded skin in mice Microbial biotechnology · 2021 · 6 citations
    6. Hypoxia-Derived Mesenchymal Stem Cell Exosomes Downregulate CXCL12 and Upregulate IL-10 Expression in a Murine Model of Androgenic Alopecia Molecular and Cellular Biomedical Sciences · 2026
    7. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025
    8. CXCL12 Drives Reversible Fibroimmune Remodeling in Androgenetic Alopecia Revealed by Single-Cell RNA Sequencing International Journal of Molecular Sciences · 2025
    9. EVALUATION OF THE ROLE OF CXCL12 IN CASES OF ALOPECIA AREATA ALEXMED ePosters · 2025
    10. Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup International Journal of Molecular Sciences · 2024
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