CXCL12 Drives Reversible Fibroimmune Remodeling in Androgenetic Alopecia Revealed by Single-Cell RNA Sequencing

    July 2025 in “ International Journal of Molecular Sciences ”
    Seungchan An, Mei Zheng, In Guk Park, Leegu Song, Jino Kim, Minsoo Noh, Jong-Hyuk Sung
    Image of study
    TLDR Blocking CXCL12 can reverse hair loss and fibrosis in androgenetic alopecia.
    This study identifies CXCL12 as a key mediator in androgenetic alopecia (AGA), linking androgen signaling to stromal and immune remodeling. Using a testosterone-induced mouse model with 45 mice, researchers found that dermal fibroblasts are the most androgen-responsive cells, producing CXCL12, which promotes fibrosis and immune cell retention. Blocking CXCL12 with a neutralizing antibody reversed these effects, reducing fibrosis, decreasing pro-fibrotic macrophage infiltration, and promoting hair regrowth. The study suggests CXCL12 as a promising therapeutic target for AGA and potentially other fibrotic skin diseases.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 7 results
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 8 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  139 upvotes 1 year ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  7 upvotes 1 year ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community Stop expecting results in 2 months!

      in Treatment  125 upvotes 1 year ago
      People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.

    Similar Research

    5 / 570 results