Therapeutic Potential of Stem Cell-Derived Exosomes in Hair Regeneration: A Systematic Review

    July 2025 in “ World Journal of Stem Cells
    Neil Poddar, Adarsh Aratikatla, Ashim Gupta
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    TLDR Stem cell-derived exosomes could be a promising new treatment for hair regrowth.
    This systematic review examines the potential of stem cell-derived exosomes in hair regeneration, highlighting their ability to promote hair growth through various biological pathways. Studies show that exosomes can enhance hair regrowth by activating pathways like Wnt/β-catenin and PI3K/AKT, reducing apoptosis, and improving follicle health. Notable findings include the use of exosomes from adipose-derived stem cells, which resulted in denser hair regrowth and increased angiogenesis, and exosomes from human hair follicle stem cells, which reversed DHT-induced miniaturization. These results suggest that exosomes could serve as a promising alternative to traditional hair loss treatments.
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