Development of Pluripotent Stem Cell-Derived Epidermal Organoids That Generate Effective Extracellular Vesicles in Skin Regeneration

    February 2024 in “ Biomaterials ”
    Sojung Kwak, Cho Lok Song, Jinhyuk Lee … Jungwoon Lee
    Studysummary In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.
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    Research cited in this study 10

    1. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    2. Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges Journal of Translational Medicine · 2020
    3. Long-Term Expansion and Differentiation of Adult Murine Epidermal Stem Cells in 3D Organoid Cultures Proceedings of the National Academy of Sciences · 2019
    4. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    5. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    6. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    7. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    8. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    9. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    10. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005