TLDR Stem cell-derived organoids can improve skin healing.
The study developed pluripotent stem cell-derived epidermal organoids (iEpiOs) that closely mimic in vivo epidermal structures and produce extracellular vesicles (EVs) with enhanced regenerative abilities. These iEpiOs, cultured in a 3D environment, exhibit stratified epidermal layers and maintain their characteristics through multiple passages. The research demonstrated that EVs from iEpiOs significantly enhance wound healing in vitro and in vivo, likely due to their enriched content of growth factors and specific miRNAs. The findings suggest that iEpiOs and their EVs hold promise for therapeutic applications in skin regeneration and wound healing, offering a potential alternative to animal models.
71 citations,
February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
67 citations,
June 2019 in “Proceedings of the National Academy of Sciences” A new 3D culture system helps grow and study mouse skin stem cells for a long time.
321 citations,
January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
101 citations,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.
168 citations,
August 2009 in “EMBO molecular medicine” Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
November 2024 in “Burns & Trauma” Skin organoids help improve wound healing and tissue repair.
August 2023 in “Military Medical Research” Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
31 citations,
January 2021 in “Experimental Dermatology” Skin organoids are a promising new model for studying human skin development and testing treatments.
21 citations,
June 2018 in “Current Opinion in Genetics & Development” Scientists have made progress in growing mini-organs and regenerating parts of the skin, with plans to treat hair loss in a future trial.
10 citations,
September 2022 in “Advanced Healthcare Materials” Current methods can't fully recreate skin and its features, and more research is needed for clinical use.
