Development of Pluripotent Stem Cell-Derived Epidermal Organoids That Generate Effective Extracellular Vesicles in Skin Regeneration

    February 2024 in “ Biomaterials ”
    Sojung Kwak, Cho Lok Song, Jinhyuk Lee, Sung‐Yeon Kim, Seungyoon Nam, Young‐Jun Park, Jungwoon Lee
    TLDR Stem cell-derived organoids can improve skin healing.
    The study developed pluripotent stem cell-derived epidermal organoids (iEpiOs) that closely mimic in vivo epidermal structures and produce extracellular vesicles (EVs) with enhanced regenerative abilities. These iEpiOs, cultured in a 3D environment, exhibit stratified epidermal layers and maintain their characteristics through multiple passages. The research demonstrated that EVs from iEpiOs significantly enhance wound healing in vitro and in vivo, likely due to their enriched content of growth factors and specific miRNAs. The findings suggest that iEpiOs and their EVs hold promise for therapeutic applications in skin regeneration and wound healing, offering a potential alternative to animal models.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 10 results

      community Has anyone tried Exosomes from Musely or somewhere else?

      in Hair Systems  10 upvotes 7 months ago
      Exosomes from Musely are being discussed as a topical hair loss treatment containing ingredients like latanoprost, caffeine, cetirizine, melatonin, vitamin D3, vitamin E, and biotin. Users are curious about its effectiveness and potential side effects, noting it may take 4-6 months to see results.

      community Please explain this Minoxidil phenomena

      in Minoxidil  57 upvotes 2 years ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 1 year ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

    Similar Research

    5 / 1000+ results