Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids

    January 2018 in “ Cell Reports ”
    Jiyoon Lee, Robert Böscke, Pei-Ciao Tang … Karl R. Koehler
    Studysummary In this study, researchers successfully derived skin organoids from mouse pluripotent stem cells that spontaneously produce hair follicles, potentially aiding in hair growth research and in vitro drug testing.
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    Research cited in this study 12

    1. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    2. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    3. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    4. Organotypic Skin Culture Systems for In Vitro Growth of Skin Tissues Journal of Investigative Dermatology · 2013
    5. Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation Scientific Reports · 2012
    6. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    7. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    8. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    9. Defining Hair Follicles in the Age of Stem Cell Bioengineering Journal of Investigative Dermatology · 2007
    10. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    11. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    12. Hair Follicle Stem Cells: Insights from the 2003 Workshop ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003