Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review

    January 2022 in “ Life ”
    José María Llamas-Molina, Alejandro Carrero-Castaño, Ricardo Ruiz-Villaverde, Antonio Campos
    Studysummary This review examines current and potential tissue engineering strategies for hair follicle regeneration in androgenetic alopecia but does not provide new clinical results, highlighting the need for further research and development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 45

    1. Detecting the Mechanism Behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus Nippon) Dermal Papilla Cells to Three-Dimensional Pattern International Journal of Molecular Sciences · 2021
    2. Design of In Vitro Hair Follicles for Different Applications in the Treatment of Alopecia: A Review Biomedicines · 2021
    3. Alopecia and Microbiome: Future Therapeutic Target? Actas Dermo-Sifiliográficas · 2021
    4. Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia International Journal of Molecular Sciences · 2020
    5. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    6. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    7. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    8. Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal? Stem Cells Translational Medicine · 2019
    9. Progenitor-Cell-Enriched Micrografts as a Novel Option for the Management of Androgenetic Alopecia Journal of Cellular Physiology · 2019
    10. Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options Expert Opinion on Therapeutic Targets · 2019
    11. Use of Extracellular Matrix Hydrogel from Human Placenta to Restore Hair-Inductive Potential of Dermal Papilla Cells Regenerative Medicine · 2019
    12. Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin Biochemical and Biophysical Research Communications · 2019
    13. Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia Dermatologic Surgery · 2019
    14. TSA Restores Hair Follicle-Inductive Capacity of Skin-Derived Precursors Scientific Reports · 2019
    15. New Drugs Under Investigation for the Treatment of Alopecias Expert Opinion on Investigational Drugs · 2019
    16. Skin Stem Cells, Their Niche, and Tissue Engineering Approach for Skin Regeneration Advances in experimental medicine and biology · 2019
    17. Are Hair Follicle Stem Cells Promising Candidates for Wound Healing? Expert Opinion on Biological Therapy · 2018
    18. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    19. Inducing Hair Follicle Neogenesis with Secreted Proteins Enriched in Embryonic Skin Biomaterials · 2018
    20. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017
    21. Conventional and Novel Stem Cell-Based Therapies for Androgenic Alopecia Stem cells and cloning · 2017
    22. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    23. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    24. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017
    25. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    26. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    27. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    28. Hair Restoration Surgery: Challenges and Solutions Clinical, Cosmetic and Investigational Dermatology · 2015
    29. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    30. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    31. Adipose Derived Stem Cells and Growth Factors Applied in Hair Transplantation: Follow-Up of Clinical Outcome Journal of Cosmetics, Dermatological Sciences and Applications · 2014
    32. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    33. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    34. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    35. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    36. Hair Follicular Cell/Organ Culture in Tissue Engineering and Regenerative Medicine Biochemical Engineering Journal · 2009
    37. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    38. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    39. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    40. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    41. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    42. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    43. Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles Experimental Dermatology · 2002
    44. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    45. The Secret Life of the Hair Follicle Trends in genetics · 1992

    Related research 9

    1. Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review Life · 2022
    2. New Idea for Hair Transplantation to Preserve More Donor Hair Follicles Medical Hypotheses · 2019
    3. Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia Journal of Investigative Dermatology · 2018
    4. Platelet-Rich Plasma: The Ultimate Secret for Youthful Skin Elixir and Hair Growth Triggering Journal of Cosmetic Dermatology · 2017
    5. Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc. Elsevier eBooks · 2017
    6. The Latest Innovations in Hair Transplantation Facial Plastic Surgery · 2011
    7. Use of Micrografts and Minigrafts in Hair Restoration Clinics in Plastic Surgery · 2005
    8. Autogenous Hair Transplantation in Treatment of Seborrheic Hair Loss: An Analysis of 3000 Cases Chinese Journal of Medical Aesthetics and Cosmetology · 2004
    9. Indications for Micrograft Hair Transplantation PubMed · 2002