Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review

    January 2022 in “ Life
    José María Llamas-Molina, Alejandro Carrero-Castaño, Ricardo Ruiz-Villaverde, Antonio Campos
    Image of study
    TLDR Tissue engineering could be a future solution for hair loss, but it's currently expensive, complex, and hard to apply in real-world treatments.
    The document "Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review" discusses the potential of tissue engineering as a future solution for Androgenetic Alopecia (AGA). Current treatments often fail to provide satisfactory results and can cause side effects. The review evaluates present and emerging hair follicle bioengineering strategies, highlighting the role of Dermal Papilla Cells (DPCs) and Hair Follicle Stem Cells (HFSCs) in hair follicle regeneration. The document also discusses the potential of hair follicle cloning in regenerative medicine for AGA treatment. However, despite significant advances, the main challenges are the high cost, complexity, and the difficulty of translating these techniques into clinical practice.
    Discuss this study in the Community →

    Research cited in this study

    43 / 43 results

    Related Community Posts Join

    6 / 855 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Story time! The Great Unbalding (PP405)

      in Research/Science  229 upvotes 1 month ago
      PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Unpopular Opinion: hair cloning kind of sucks as a potential future cure.

      in Technology  26 upvotes 9 months ago
      Hair cloning is seen as a distant and potentially less relevant solution for hair loss due to its high cost, invasiveness, and the advancement of other treatments like Minoxidil and finasteride. Many believe that by the time hair cloning becomes viable, other less invasive and more effective treatments will be available.

      community Beyond Minoxidil & Finasteride: What if the Answer to Male Pattern Baldness is... on Our Faces? (A Naval Officer's Wild Idea & Why It's Not So Crazy)

      in What should I do? 3 weeks ago
      Exploring the idea of using facial hair properties for scalp regeneration in male pattern baldness, considering the potential of transferring androgen-resistant characteristics from facial hair to the scalp. Challenges include complexity, scalability, aesthetics, and safety, but the concept encourages innovative thinking beyond current treatments like Minoxidil, Finasteride, and hair transplants.

    Related Research

    9 / 9 results