Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

    October 2012 in “ Biomaterials ”
    Yi-Ching Huang, Chih-Chieh Chan, Wei-Ting Lin … Sung-Jan Lin
    Studysummary This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.
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    Research cited in this study 17

    1. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    2. Sostdc1 Defines the Size and Number of Skin Appendage Placodes Developmental biology · 2012
    3. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011
    4. Large-Scale Cultivation of Transplantable Dermal Papilla Cellular Aggregates Using Microfabricated PDMS Arrays Acta Biomaterialia · 2010
    5. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    6. The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility Biomaterials · 2009
    7. Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials · 2008
    8. Defining Hair Follicles in the Age of Stem Cell Bioengineering Journal of Investigative Dermatology · 2007
    9. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    10. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    11. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    12. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    13. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004
    14. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    15. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    16. Epithelial Growth by Rat Vibrissae Follicles In Vitro Requires Mesenchymal Contact via Native Extracellular Matrix Journal of Investigative Dermatology · 1990
    17. Physiology of Development of the Feather V: Experimental Morphogenesis Physiological zoology · 1941

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