Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

    October 2012 in “ Biomaterials ”
    Yi-Ching Huang, Chih-Chieh Chan, Wei-Ting Lin, Hsien-Yi Chiu, Ren-Yeu Tsai, Tsung-Hua Tsai, Jung-Yi Chan, Sung-Jan Lin
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    TLDR Larger spheroids improve hair growth, but size doesn't guarantee thicker hair.
    This document is a scientific paper from 10 years ago that explores the production of controllable dermal papilla (DP) spheroids on PVA surfaces and the effects of spheroid size on hair follicle (HF) regeneration. The researchers found that larger spheroids exhibit higher HF inductivity, but the size of the spheroid cannot be directly translated to a thicker regenerated hair. The study suggests that an appropriate size of DP spheroid is essential for HF inductivity, but further research is needed to explore the efficiency and efficacy of regeneration of other epithelial organs. The study used human dermal papilla cells and PVA surfaces, and the results suggest that spheroid size could be an important factor in hair regeneration.
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