Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

November 2006 in “ Proceedings of the National Academy of Sciences of the United States of America ”

Andrey A. Sharov, Tatyana Sharova, Andrei N. Mardaryev, Alice Tommasi di Vignano, Ruzanna Atoyan, Lorin Weiner, Shi Yang, Janice L. Brissette, G. Paolo Dotto, Vladimir A. Botchkarev

bone morphogenetic protein BMP signaling hair follicles cell cycle-associated genes p27Kip1 BMP antagonist noggin androgenetic alopecia alopecia areata BMP hair growth disorders

TLDR BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.

The study concluded that bone morphogenetic protein (BMP) signaling played a crucial role in regulating hair follicle size and modulating the expression of cell cycle-associated genes, particularly through the cell cycle inhibitor p27Kip1. Transgenic mice overexpressing the BMP antagonist noggin and p27Kip1 knockout mice exhibited larger hair follicles and increased cell proliferation. These findings suggested that BMP signaling pathways could be potential targets for therapeutic interventions in hair growth disorders such as androgenetic alopecia and alopecia areata.

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Research cited in this study

13 / 13 results

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations , September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Bone Morphogenetic Protein Signaling Controls Hair Pigmentation Through Cross-Talk With the Melanocortin Receptor-1 Pathway

70 citations , December 2004 in “Proceedings of the National Academy of Sciences”

BMP signaling affects hair color by interacting with the MC-1R pathway.

research Morpho-Regulation of Ectodermal Organs

131 citations , March 2004 in “The American journal of pathology”

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.

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research Role of Bone Morphogenetic Protein Signaling in Skin Carcinogenesis: Effect of Transgenic Overexpression of BMP Antagonist Noggin on Skin Tumor Development; Molecular Mechanisms Underlying Tumor Suppressive Role of BMP Signaling in Skin

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BMP signaling helps prevent skin tumors by blocking cancer-promoting pathways.

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

65 citations , September 2004 in “The American journal of pathology”

Blocking BMP signaling causes hair loss and disrupts hair growth cycles.

Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

Research cited in this study

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

research Bone Morphogenetic Protein Signaling Controls Hair Pigmentation Through Cross-Talk With the Melanocortin Receptor-1 Pathway

research Morpho-Regulation of Ectodermal Organs

research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

research Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

research Stimulation of Ectodermal Organ Development by Ectodysplasin-A1

research Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation

research Molecular Mechanisms Regulating Hair Follicle Development

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

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