Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

    November 2006 in “ Proceedings of the National Academy of Sciences of the United States of America ”
    Andrey A. Sharov, Tatyana Sharova, Andrei N. Mardaryev … Vladimir A. Botchkarev
    Studysummary This study found that transgenic mice overexpressing the BMP antagonist noggin showed increased hair follicle size and altered hair type, linked to changes in cell proliferation and gene expression.
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    Research cited in this study 13

    1. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    2. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    3. Bone Morphogenetic Protein Signaling Controls Hair Pigmentation Through Cross-Talk With the Melanocortin Receptor-1 Pathway Proceedings of the National Academy of Sciences · 2004
    4. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    5. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    6. Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation EMBO journal · 2003
    7. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    8. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    9. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    10. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    11. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    12. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    13. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999

    Related research 2

    1. Role of Bone Morphogenetic Protein Signaling in Skin Carcinogenesis: Effect of Transgenic Overexpression of BMP Antagonist Noggin on Skin Tumor Development; Molecular Mechanisms Underlying Tumor Suppressive Role of BMP Signaling in Skin Bradford Scholars (University of Bradford) · 2009
    2. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004