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Glossary Noggin

protein inhibiting BMPs, crucial for hair follicle development

Noggin is a protein that plays a crucial role in the development and growth of various tissues, including hair follicles. It functions by inhibiting bone morphogenetic proteins (BMPs), which are involved in the regulation of cell growth and differentiation. By modulating BMP activity, Noggin helps maintain the balance necessary for proper hair follicle formation and cycling.

Research

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research Noggin is required for induction of the hair follicle growth phase in postnatal skin

211 citations , October 2001 in “The FASEB Journal”

This study found that the BMP antagonist noggin induces hair growth in postnatal skin by neutralizing BMP4's inhibitory activity, potentially mediated by changes in Shh expression.

research Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop

138 citations , June 2012 in “Genes & Development”

This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.

research Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation

65 citations , June 2003 in “EMBO journal”

This study reports that overexpressing the BMP antagonist noggin in mice inhibits eyelid opening by reducing apoptosis and delaying cell differentiation in the eyelid epithelium.

research The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects

49 citations , January 2006 in “Developmental Dynamics”

This research observed that the skeletal abnormalities in Noggin null mice varied based on genetic background, and identified haploinsufficiency leading to joint fusions, similar to human conditions associated with NOGGIN deficiency.

research Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways

45 citations , August 2009 in “American Journal Of Pathology”

Noggin promotes skin tumors by activating certain cell signaling pathways.

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Clinics

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SMP
Noggin Master StudiosPittsburgh, PA · US

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