Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

    November 2003 in “ The Journal of Cell Biology ”
    Krzysztof Kobielak, H. Amalia Pasolli, Laura Alonso … Elaine Fuchs
    Studysummary This study found that BMP receptor IA is crucial for hair progenitor cell differentiation in mice, and its sequential inhibition and activation are necessary to generate a functioning hair shaft.
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    Research cited in this study 17

    1. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003
    2. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    3. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002
    4. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    5. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    6. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    7. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    8. Formation of Regulator/Target Gene Relationships During Evolution Gene · 2000
    9. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    10. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    11. Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia Developmental biology · 1999
    12. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    13. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    14. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998
    15. The Secret Life of the Hair Follicle Trends in genetics · 1992
    16. Dermal-Epidermal Interactions in Hair Follicle Development and Cycling Clinics in dermatology · 1988
    17. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986

    Related research 4

    1. Role of Bone Morphogenetic Protein Signaling in Skin Carcinogenesis: Effect of Transgenic Overexpression of BMP Antagonist Noggin on Skin Tumor Development; Molecular Mechanisms Underlying Tumor Suppressive Role of BMP Signaling in Skin Bradford Scholars (University of Bradford) · 2009
    2. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004
    3. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    4. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981