Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

August 1999 in “ Developmental biology ”

David M. Prowse, David Lee, Lorin Weiner, Nanyan Jiang, Cynthia M. Magro, Howard P. Baden, Janice L. Brissette

Whn gene cutaneous epithelia epidermis hair follicles TGF-alpha basal keratinocytes hyperproliferation hyperplasia hydronephrosis skin cells hair growth transforming growth factor alpha skin basal cells excessive cell growth kidney swelling

Studysummary This study found that ectopic expression of Whn in transgenic mice caused impaired differentiation in epidermis and hair follicles, with hair growth defects and severe urinary tract issues leading to hydronephrosis.

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