Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools

The "Handbook of Mouse Mutations with Skin and Hair Abnormalities" served as a comprehensive resource for understanding various genetic mutations in laboratory mice that affected skin and hair, providing valuable models for dermatological research. It covered a wide range of topics, including the biology of skin and hair in mice and humans, the use of inbred laboratory mice as models, and specific mutations affecting hair and skin, such as the hairless (hr) and rhino (hrrh) mutations on chromosome 14. The document also discussed the role of hair follicle stem cells, growth factors, and cytokine mutations in cutaneous pathology. Additionally, it explored the immune system's involvement in skin diseases and the search for mouse models of conditions like psoriasis. The handbook highlighted the importance of these models in studying genetic-based skin diseases and their potential applications in biomedical research.