Molecular Mechanisms Regulating Hair Follicle Development
February 2002
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
WNT Sonic Hedgehog SHH BMP hair follicle development hair follicle cycling dermal-epidermal interactions stem cells hair follicle morphogenesis hair follicle renewal genetic factors mutations dl gene Sox18 gene Msx2 gene WNT pathway Sonic Hedgehog pathway Bone Morphogenetic Protein hair growth hair structure stem cell therapy
TLDR Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
The document "Molecular Mechanisms Regulating Hair Follicle Development" from 2002 reviewed the complex signaling pathways and genetic factors involved in hair follicle development and cycling. Key pathways such as WNT, Sonic Hedgehog (SHH), and BMP were crucial for hair growth and structure, with mutations in genes like dl, Sox18, and Msx2 linked to hair follicle defects. The study highlighted the importance of dermal-epidermal interactions and stem cells in hair follicle morphogenesis and renewal. It emphasized the roles of WNT and SHH in initiating and maintaining hair growth phases, and noted the potential therapeutic applications and risks of these pathways in treating hair loss conditions. The findings underscored the need for further research to fully understand these mechanisms and their therapeutic potential.
