Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells

August 2014 in “ Journal of clinical & experimental dermatology research ”

Jack Sung

platelet-released growth factors androgenetic alopecia hair follicle stem cells 5-alpha-reductase pathway chronic micro inflammation fibrosis PDGF Platelet Derived Growth Factor VEGF Vascular Endothelial Growth Factor tricoscopy AGA hair regrowth hair density

TLDR Platelet-released growth factors can treat hair loss by activating hair follicle stem cells, blocking certain pathways, and controlling inflammation and fibrosis.

Nine years ago, a study was conducted on the use of platelet-released growth factors for treating androgenetic alopecia (AGA) by activating hair follicle stem cells. AGA, a common disease affecting over 50% of the male population over 50 years old in the United States, was found to be caused by an abnormality of stem cells failing to convert into progenetic cells. The study designed an advanced hair regrowth course focusing on activating bulge hair follicle stem cells, blocking the 5-alpha-reductase pathway, and controlling chronic micro inflammation and fibrosis. The treatment involved delivering PDGF (Platelet Derived Growth Factor) and VEGF (Vascular Endothelial Growth Factor) isolated from platelets. The effectiveness of the treatment was validated by recording global images and tricoscopy of each treatment. A hair growth course of 4 deliveries was indicated for each patient on a monthly basis, with the goal of reaching a hair density of 120 hairs per square centimeter.

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