Male Androgenetic Alopecia Is Due to Hair Follicle Stem Cell Inactivation

    April 2011 in “ Expert Review of Dermatology ”
    Longmei Zhao, Basil M. Hantash
    Studysummary This review examines a study showing that the balding scalp in men with androgenetic alopecia retains stem cells but lacks certain progenitor cells, suggesting new targets for future therapies; it reports no clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on tandfonline.com →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    2. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    3. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    4. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    5. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    6. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    7. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    8. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    9. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    10. The Genetics of Androgenetic Alopecia Clinics in Dermatology · 2001
    11. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    12. The Inheritance Of Common Baldness: To Be Or Not To Be? Journal of the American Academy of Dermatology · 1984

    Related research 6

    1. Androgenetic Alopecia Pattern Hair Regrowth in Patients with Alopecia Areata Treated with Oral JAK Inhibitors Journal of The American Academy of Dermatology · 2020
    2. Hair and Scalp Diseases CRC Press eBooks · 2008
    3. Indications for Micrograft Hair Transplantation PubMed · 2002
    4. Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia Archives of Dermatology · 1997
    5. Clinical Updates in Hair Dermatologic Clinics · 1997
    6. Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up Dermatology · 1987