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GlossaryDiffuse Alopecia (DP)

widespread hair thinning across the entire scalp

Diffuse Alopecia, also known as Diffuse Hair Loss or Diffuse Thinning, is a condition characterized by a widespread thinning of hair across the entire scalp rather than in localized patches. This type of hair loss can be caused by various factors, including nutritional deficiencies, hormonal imbalances, stress, or underlying medical conditions, and it typically does not result in scarring of the scalp.

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research Vertex and Occipital Intermediate and Terminal Hair Follicles from Androgenetic Alopecia Patients are Differentially Affected by Testosterone Ex Vivo

November 2022 in “Journal of Investigative Dermatology”

Occipital hair follicles in male pattern baldness respond uniquely to testosterone, not androgen-insensitive.

research Accelerated Aging of Hair Follicles in Androgenetic Alopecia

May 2024 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair follicles in androgenetic alopecia age faster, especially in the front.

research Estetrol Prolongs Anagen Ex Vivo: Does E4 Have Potential as a Novel Strategy to Treat Female Pattern Hair Loss?

September 2024 in “Journal of the American Academy of Dermatology”

Estetrol (E4) may help treat female pattern hair loss by prolonging hair growth.

Single-Cell RNA Sequencing of Different Fibroblast Populations Cultured from Female Scalp Reveals Significant Alterations to Transcriptional Profiles with Age

research Single-Cell RNA Sequencing of Different Fibroblast Populations Cultured from Female Scalp Reveals Significant Alterations to Transcriptional Profiles with Age

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Aging changes female scalp cells, likely affecting hair health.

research Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression

2 citations, February 2019 in “Journal of Investigative Dermatology”

Higher levels of the DP2 receptor may lead to hair loss.

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community Information regarding Follicusan DP?

in Product 3 upvotes 1 year ago

Follicusan DP is discussed as a potential alternative to Minoxidil without side effects, but information is scarce. It is noted to be of German origin and details on its mechanism are limited.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 2 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Shiseido filed for this patent in May 2019. Let's get some big brain discussion on this.

6 upvotes 5 years ago

The conversation discusses a patent filed by Shiseido for cloning Dermal Papilla (DP) cells to treat hair loss. The method involves using viral vectors to maintain the cells' growth-inducing properties, differing from Replicel's approach with Dermal Sheath Cup (DSC) cells.

community Show of hands (US people), who's ordering pyrilutamide?

in Treatment 8 upvotes 7 months ago

People are discussing ordering pyrilutamide for hair loss treatment in the US. The treatment is from Kintor's subsidiary company and is available on Amazon.

community Hair Growth Journey: 10 months

in Progress Pictures 252 upvotes 9 months ago

A 31-year-old who experienced severe hair loss during medical school tried various treatments, including topical and oral finasteride and minoxidil, but stopped due to side effects. They restarted treatment 10 months ago with a regimen including topical finasteride, minoxidil, retinoic acid, hydrocortisone, oral minoxidil, and light therapy, emphasizing the importance of consistency and skincare.

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