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GlossaryDipeptidyl Peptidase-4

enzyme that breaks down incretin hormones, regulating insulin levels

Dipeptidyl Peptidase-4 (DPP-4) is an enzyme that plays a role in glucose metabolism by breaking down incretin hormones, which help regulate insulin levels in the body. It is also known as CD26 and is involved in immune system functions. Inhibitors of DPP-4 are used in the treatment of type 2 diabetes to improve blood sugar control.

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973 Dipeptidyl-peptidase 4 (DPP4)-positive fibroblasts are responsible for secretion of pro-fibrotic matrix proteins in the human skin

research 973 Dipeptidyl-peptidase 4 (DPP4)-positive fibroblasts are responsible for secretion of pro-fibrotic matrix proteins in the human skin

May 2019 in “Journal of Investigative Dermatology”

DPP4-positive fibroblasts play a major role in producing proteins that lead to skin fibrosis.

research Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration

May 2023 in “Journal of Investigative Dermatology”

Blocking DPP4 can potentially speed up hair growth and regeneration, especially after injury or in cases of hair loss.

research 613 Bacteria induce skin regeneration via IL-1β signaling

May 2021 in “Journal of Investigative Dermatology”

Bacteria can help skin regenerate through a process called IL-1β signaling.

research 1434 Role of fibroblast DPP4 in wound healing, scarring and regeneration

May 2018 in “Journal of Investigative Dermatology”

DPP4 is important for scarring and skin regeneration, and managing its activity could improve skin healing treatments.

research Basic mechanisms of SARS-CoV-2 infection. What endocrine systems could be implicated?

14 citations , July 2021 in “Reviews in endocrine and metabolic disorders”

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

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