Topical Immunotherapy of Severe Alopecia Areata with Diphenylcyclopropenone: Experience in an Iranian Population

May 2005 in “ BMC dermatology ”

Shahin Aghaei

diphenylcyclopropenone DPCP alopecia areata hair regrowth eczematous reactions occipital lymphadenopathy severe eczema blister formation hyperpigmentation

TLDR DPCP is effective for treating severe alopecia areata, but relapse is common.

The 2005 study investigated the effectiveness of diphenylcyclopropenone (DPCP) in treating severe alopecia areata in 54 Iranian patients. Results showed that 85% experienced significant hair regrowth, with 81.5% showing hair re-growth after 6-12 months of treatment. However, 50.9% of responders had partial recurrence within 6-12 months of follow-up. Side effects included eczematous reactions, occipital lymphadenopathy, severe eczema/blister formation, and hyperpigmentation. The study concluded that while DPCP is effective, it has a high relapse rate during maintenance treatment, marking the first experience with DPCP in Iran.

View this study on bmcdermatol.biomedcentral.com →

Discuss this study in the Community →

Cited in this study

8 / 8 results

research Restoration of Hair Growth with Topical Diphenylcyclopropenone in Mouse and Rat Models of Alopecia Areata

12 citations , December 2003 in “Journal of the American Academy of Dermatology”

Topical diphencyprone helped regrow hair in mice and rats with a condition similar to human hair loss.

research TREATMENT OF ALOPECIA AREATA

48 citations , October 1996 in “Dermatologic clinics”

Some treatments can help with hair regrowth in alopecia areata, but results vary and long-term use is often needed without changing the disease's outcome.

research Alopecia Areata

49 citations , November 1992 in “Archives of dermatology”

Different treatments for alopecia areata have varying success rates and side effects; intralesional steroids are most effective.

research Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata

101 citations , November 1992 in “Archives of Dermatology”

Steroids help hair regrowth, and minoxidil slows post-steroid hair loss, but effects are temporary.

research Treatment-resistant alopecia areata. Response to combination therapy with minoxidil plus anthralin

36 citations , June 1990 in “Archives of Dermatology”

Using minoxidil and anthralin together can improve hair regrowth in severe alopecia areata patients who didn't respond to individual treatments.

research Treatment-Resistant Alopecia Areata

46 citations , June 1990 in “Archives of dermatology”

Combining 5% minoxidil and 0.5% anthralin can help regrow hair in some severe alopecia areata patients.

research Evaluation of Anthralin in the Treatment of Alopecia Areata

109 citations , November 1987 in “Archives of dermatology”

Anthralin cream helped 25% of patients with severe alopecia areata regrow hair, but caused skin irritation.

research Topical minoxidil solution (1% and 5%) in the treatment of alopecia areata

101 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.

2 / 2 results

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , March 2019 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research Treating Resistant Cases of Alopecia Universalis

May 2018 in “Journal of cosmetology & trichology”

Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.