TLDR Topical diphencyprone helped regrow hair in mice and rats with a condition similar to human hair loss.
In a study from December 2003, researchers investigated the effectiveness of diphencyprone (DPCP), a contact sensitizer, as a treatment for alopecia areata (AA) using mouse and rat models. The animals were treated with topical DPCP on one side of their body, while the other side received only a vehicle treatment. The majority of both mice and rats showed hair regrowth on the DPCP-treated side. Additionally, histologic analysis of skin biopsy specimens indicated a reduction in CD8+ lymphocyte infiltrates within hair follicles after successful treatment in mice. These findings suggest that the rodent models of AA can be valuable for understanding the human condition and the mechanisms of DPCP treatment.
Cited in this study
4 / 4 results
118 citations
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April 1998 in “Dermatologic Clinics” Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.
48 citations
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October 1996 in “Dermatologic clinics” Some treatments can help with hair regrowth in alopecia areata, but results vary and long-term use is often needed without changing the disease's outcome.
36 citations
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October 1996 in “Dermatologic Clinics” Mice are useful for researching human hair loss and testing treatments, despite some differences between species.
41 citations
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November 1993 in “Journal of The American Academy of Dermatology” DPCP helps treat severe hair loss, but 5% minoxidil doesn't add benefits.
148 citations
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March 2019 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
May 2018 in “Journal of cosmetology & trichology” Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.
370 citations
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September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
26 citations
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January 1994 in “McGraw-Hill eBooks” Many hair loss conditions can be treated.
