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GlossaryDiphenylcyclopropenone (diphencyprone)

topical immunotherapy agent used to treat alopecia areata

Diphenylcyclopropenone (DPCP) is a topical immunotherapy agent used primarily to treat alopecia areata, a condition that causes hair loss. It works by inducing a mild allergic reaction on the scalp, which is thought to distract the immune system from attacking hair follicles, thereby promoting hair regrowth.

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research Tropical Diphencyprone Therapy in Alopecia Totalis

5 citations , July 1988 in “British journal of dermatology/British journal of dermatology, Supplement”

Diphencyprone therapy can effectively treat severe hair loss in motivated patients.

Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

research Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

59 citations , October 2012 in “Pharmaceutical Research”

Squalene-based carriers improve delivery of a treatment to hair follicles for alopecia areata.

research The Use of Diphencyprone in Dermatology: A Retrospective Audit

March 2005 in “Journal of The American Academy of Dermatology”

Diphencyprone treatment protocols could be simplified as no harm occurred despite not fully following them.

research The Biphasic Regulatory Effect of Diphencyprone on Mouse Hair Growth and Its Relation to Protein Kinase C Isoforms

March 1998 in “Journal of dermatological science”

Diphencyprone initially increases mouse hair growth, then slows it, possibly due to changes in specific protein levels.

research Restoration of Hair Growth with Topical Diphenylcyclopropenone in Mouse and Rat Models of Alopecia Areata

12 citations , November 2003 in “Journal of the American Academy of Dermatology”

Topical diphencyprone helped regrow hair in mice and rats with a condition similar to human hair loss.

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