Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells

The study investigated the use of squarticles, a type of lipid nanoparticle, for delivering diphencyprone (DPCP) and minoxidil to hair follicles and human dermal papilla cells. The results showed that squarticles were effective in delivering the drugs to the hair follicles, with the squalene and fatty esters in the squarticles increasing drug uptake. The study also found that the nanoparticle size was less important for follicular entrance than follicular density, and that the NLC type of squarticles showed the highest upregulation of VEGF expression in dermal papilla cells, which is important for hair growth. The cytotoxicity assay showed that the squarticles were not toxic to the cells. Overall, the study suggests that squarticles could be a promising lipid nanocarrier for delivering drugs to hair follicles and promoting hair growth.