Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

    June 2009 in “ Journal of Pharmaceutical Sciences ”
    Jeffrey E. Grice, Susan Ciotti, Norman D. Weiner, Peter Lockwood, Sheree E. Cross, Michael S. Roberts
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    TLDR Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.
    This study examined the uptake of minoxidil, a hair growth promoting agent, into appendages, stratum corneum, and through human skin, under the influence of different vehicles. The study found that deposition of minoxidil into appendages, stratum corneum, and skin penetration into receptor fluid were similar in magnitude. Transport by the appendageal route is likely to be a key determinant of hair growth promotion by minoxidil. The study also showed that ethanol-containing formulations caused significantly greater minoxidil retention in stratum corneum and appendages, compared to the formulation lacking ethanol. A significant increase in minoxidil receptor penetration occurred with the propylene glycol-rich formulation after 12 hours.
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      community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

      in Minoxidil  39 upvotes 5 years ago
      Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

      community Tretinoin can make it worse!!!

      in Chat  7 upvotes 1 year ago
      Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

      community Trying to regrow crown been on Fin for 4.5 years

      in Finasteride/Dutasteride  6 upvotes 7 months ago
      The user has been on finasteride for 4.5 years and minoxidil for 10 years, maintaining hair but not regrowing much on the crown and temples. They are considering using a dermastamp more frequently and possibly trying RU58841, but are hesitant about dutasteride due to concerns about side effects and DHT suppression.

      community Why do I see so many people here recommend microneedling?

      in Microneedling  105 upvotes 1 year ago
      The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

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