Minoxidil: mechanisms of action on hair growth

    February 2004 in “ British Journal of Dermatology
    Andrew G. Messenger, J Rundegren
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    TLDR Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.
    The article discusses the mechanisms of action of minoxidil on hair growth. Minoxidil stimulates hair growth by opening potassium channels, which can lead to increased DNA synthesis and cell proliferation. It also prolongs anagen and increases hair follicle size. Minoxidil inhibits collagen production, stimulates PGE₂ synthesis, inhibits prostacyclin production, and stimulates VEGF synthesis by dermal papilla cells. Clinical trials have shown that topical minoxidil can be effective in treating androgenetic alopecia in men.
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