Minoxidil: Mechanisms of Action on Hair Growth

    February 2004 in “ British Journal of Dermatology ”
    Andrew G. Messenger, J Rundegren
    Studysummary This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on academic.oup.com →
    Discuss this study in the Community →

    Research cited in this study 44

    1. Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes Skin Pharmacology and Physiology · 2009
    2. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    3. Effect of Latanoprost on Hair Growth in the Bald Scalp of the Stump-Tailed Macaque: A Pilot Study 2002
    4. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001
    5. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    6. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment Journal of The American Academy of Dermatology · 1999
    7. The Induction by Topical Minoxidil of Increased Fenestration in the Perifollicular Capillary Wall British Journal of Dermatology · 1999
    8. Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp Journal of Dermatological Science · 1999
    9. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    10. Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases Chemico-Biological Interactions · 1998
    11. Hypertrichosis and Increased Pigmentation of Eyelashes and Adjacent Hair in the Region of the Ipsilateral Eyelids of Patients Treated with Unilateral Topical Latanoprost American Journal of Ophthalmology · 1997
    12. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997
    13. Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women Journal of The American Academy of Dermatology · 1996
    14. In the Absence of Streptomycin, Minoxidil Potentiates the Mitogenic Effects of Fetal Calf Serum, Insulin-Like Growth Factor 1, and Platelet-Derived Growth Factor on NIH 3T3 Fibroblasts in a K+ Channel-Dependent Fashion Journal of Investigative Dermatology · 1996
    15. Inhibitory Effects of bFGF, VEGF, and Minoxidil on Collagen Synthesis by Cultured Hair Dermal Papilla Cells Archives of Dermatological Research · 1996
    16. Effects of Hypertrichotic Agents on Follicular and Nonfollicular Cells In Vitro Skin Pharmacology and Physiology · 1996
    17. Effect of Minoxidil Sulfate and Pinacidil on Single Potassium Channel Current in Cultured Human Outer Root Sheath Cells and Dermal Papilla Cells Journal of Dermatological Science · 1994
    18. Minoxidil Sulfation in the Hair Follicle Skin Pharmacology and Physiology · 1994
    19. Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts Archives of Biochemistry and Biophysics · 1994
    20. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    21. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993
    22. Organ Culture of Human Hair Follicles in Serum-Free Medium Archives of Dermatological Research · 1993
    23. Potassium Channel Openers Stimulate DNA Synthesis in Mouse Epidermal Keratinocyte and Whole Hair Follicle Cultures Skin Pharmacology and Physiology · 1993
    24. Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil Biochemical Pharmacology · 1993
    25. Minoxidil Sulfotransferase, A Marker Of Human Keratinocyte Differentiation Journal of Investigative Dermatology · 1992
    26. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    27. Interaction of Minoxidil with Pigment in Cells of the Hair Follicle: An Example of Binding Without Apparent Biological Effects Skin Pharmacology and Physiology · 1992
    28. Minoxidil: Inhibition of Proliferation of Keratinocytes In Vitro Journal of Investigative Dermatology · 1991
    29. Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles Journal of Investigative Dermatology · 1991
    30. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    31. Sulfation of Minoxidil by Human Liver Phenol Sulfotransferase Biochemical Pharmacology · 1990
    32. Biochemical and Trichological Characterization of Diffuse Alopecia in Women British Journal of Dermatology · 1990
    33. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990
    34. Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture Journal of Investigative Dermatology · 1989
    35. Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia Clinics in Dermatology · 1988
    36. Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture Biochemical Pharmacology · 1988
    37. Sulfation of Minoxidil by Human Platelet Sulfotransferase Clinica Chimica Acta · 1987
    38. Alterations in Scalp Blood Flow After the Epicutaneous Application of 3% Minoxidil and 0.1% Hexyl Nicotinate in Alopecia British Journal of Dermatology · 1987
    39. Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil Journal of Biological Chemistry · 1987
    40. Action of Topical Minoxidil in the Bald Stump-Tailed Macaque Journal of The American Academy of Dermatology · 1987
    41. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984
    42. Effect of Minoxidil on Cultured Keratinocytes Journal of Investigative Dermatology · 1983
    43. Sulfation of Minoxidil by Liver Sulfotransferase Biochemical Pharmacology · 1982
    44. Minoxidil in Severe Hypertension with Renal Failure American Journal of Cardiology · 1973