Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

January 1991 in “ Journal of Investigative Dermatology ”

Thomas P. Dooley, Cynthia J. Walker, Sharon J. Hirshey, Charles N. Falany, A. R. Diani

minoxidil minoxidil sulfotransferase MST anagen hair follicles outer root sheath hair growth Rogaine

TLDR Minoxidil works in liver and outer hair root sheath for hair growth.

This study from 1991 aimed to determine the site(s) of action of minoxidil, a drug used to stimulate hair growth. The researchers found that minoxidil sulfotransferase (MST) is present in the liver and the outer root sheath of anagen hair follicles in rats. This suggests that the lower outer root sheath of the hair follicle may serve as a site for the sulfation of topically applied minoxidil. The study provides insight into the localization of MST in hair follicles and its potential role in hair growth.

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Research cited in this study

9 / 9 results

Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

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Liver enzyme helps minoxidil work better for blood vessel relaxation.

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research Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

46 citations, January 1991 in “Journal of Investigative Dermatology”

Minoxidil works in liver and outer hair root sheath for hair growth.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

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Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

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