Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

January 1991 in “ Journal of Investigative Dermatology ”

Thomas P. Dooley, Cynthia J. Walker, Sharon J. Hirshey, Charles N. Falany, A. R. Diani

minoxidil minoxidil sulfotransferase MST anagen hair follicles outer root sheath hair growth Rogaine

TLDR Minoxidil works in liver and outer hair root sheath for hair growth.

This study from 1991 aimed to determine the site(s) of action of minoxidil, a drug used to stimulate hair growth. The researchers found that minoxidil sulfotransferase (MST) is present in the liver and the outer root sheath of anagen hair follicles in rats. This suggests that the lower outer root sheath of the hair follicle may serve as a site for the sulfation of topically applied minoxidil. The study provides insight into the localization of MST in hair follicles and its potential role in hair growth.

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Research cited in this study

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research Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

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Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

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Minoxidil effectively regrows hair in male pattern baldness.

research Dose-Response Study of Topical Minoxidil in Male Pattern Baldness

58 citations , July 1986 in “Journal of The American Academy of Dermatology”

Lowest effective minoxidil concentration is 1%, but 2% works better for male pattern baldness.

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research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations , May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

research Sulfation of Minoxidil by Liver Sulfotransferase

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Liver enzyme helps minoxidil work better for blood vessel relaxation.

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community Oral Minoxidil - The Hyper-Responder Concept

in Research/Science 6 upvotes 1 month ago

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in Minoxidil 316 upvotes 4 months ago

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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research Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

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