Minoxidil Sulfation in the Hair Follicle

January 1994 in “ Skin Pharmacology and Physiology ”

C. Scott Baker, Hideo Uno, G. Allan Johnson

minoxidil minoxidil sulfotransferase hair follicle androgenetic alopecia scalp skin Rogaine

TLDR Minoxidil helps hair growth by activating enzymes in hair follicles.

This study investigated the presence of minoxidil sulfotransferase activity in the scalp skin of stumptailed macaques and found that most of the sulfotransferase activity was present in the hair follicle, indicating that this activity may account for minoxidil's ability to stimulate hair growth in this animal model. The study provides insight into the mechanism of minoxidil's action and its potential use in treating androgenetic alopecia.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 5 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Is microneedling + minoxidil better than oral minoxidil

in Chat 29 upvotes 5 months ago

Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 75 upvotes 9 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Why don't Minoxidil regenerated hairs become terminal on the head?

in Minoxidil 102 upvotes 2 weeks ago

Minoxidil helps hair growth by increasing blood flow and prolonging the growth phase, but it doesn't address the root cause of hair loss, such as DHT sensitivity. Finasteride can help maintain some gains by blocking DHT, but stopping Minoxidil often leads to hair loss because the new hairs are dependent on it.

community Tretinoin can make it worse!!!

in Chat 7 upvotes 1 year ago

Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

community When are we getting a cure to hair loss?

in Chat 2 years ago

Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.