TLDR Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
This study found that human platelets can convert minoxidil to minoxidil sulfate, which is essential for its vasodilator activity. The researchers also discovered inter-subject variations in sulfotransferase activity. However, the significance of platelet sulfotransferase in the pharmacologic action of minoxidil is difficult to assess, as the liver is recognized as the major site of sulfation.
Cited in this study
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66 citations
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September 1982 in “Biochemical Pharmacology” Liver enzyme helps minoxidil work better for blood vessel relaxation.
59 citations
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February 1998 in “Chemico-Biological Interactions” Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.
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May 1992 in “Journal of Investigative Dermatology” Minoxidil sulfotransferase is a marker of keratinocyte differentiation and may play a role in hair growth.
39 citations
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November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
66 citations
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September 1982 in “Biochemical Pharmacology” Liver enzyme helps minoxidil work better for blood vessel relaxation.