Sulfation of Minoxidil by Human Platelet Sulfotransferase

    November 1987 in “ Clinica Chimica Acta ”
    Garland A. Johnson, Carolyn D. Baker
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    TLDR Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
    This study found that human platelets can convert minoxidil to minoxidil sulfate, which is essential for its vasodilator activity. The researchers also discovered inter-subject variations in sulfotransferase activity. However, the significance of platelet sulfotransferase in the pharmacologic action of minoxidil is difficult to assess, as the liver is recognized as the major site of sulfation.
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