Sulfation of Minoxidil by Human Platelet Sulfotransferase

November 1987 in “ Clinica Chimica Acta ”

Garland A. Johnson, Carolyn D. Baker

minoxidil minoxidil sulfate sulfotransferase vasodilator platelets liver Rogaine

TLDR Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

This study found that human platelets can convert minoxidil to minoxidil sulfate, which is essential for its vasodilator activity. The researchers also discovered inter-subject variations in sulfotransferase activity. However, the significance of platelet sulfotransferase in the pharmacologic action of minoxidil is difficult to assess, as the liver is recognized as the major site of sulfation.

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research Sulfation of Minoxidil by Liver Sulfotransferase

66 citations, September 1982 in “Biochemical Pharmacology”

Liver enzyme helps minoxidil work better for blood vessel relaxation.

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