Sulfation of Minoxidil by Liver Sulfotransferase

    September 1982 in “ Biochemical Pharmacology ”
    Garland A. Johnson, Barsuhn Karen, John McCall
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    TLDR Liver enzyme helps minoxidil work better for blood vessel relaxation.
    The study investigated the sulfation of minoxidil by liver sulfotransferase in rats. The researchers found that the enzyme activity was specific to certain substrates, and that minoxidil sulfate had direct vasodilator activity when administered to dogs and rats. The study concluded that the enzyme-catalyzed sulfation of N-oxides extends the spectrum of sulfotransferase activities, and provides an additional direction for future studies on the disposition of xenobiotics.
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      community Minoxidil Sulfate makes everyone a responder

      in Research/Science  255 upvotes 1 week ago
      Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

      community Sublingual Minoxidil - Cure to Hairloss?

      in Minoxidil  583 upvotes 1 year ago
      The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

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