Sulfation of Minoxidil by Liver Sulfotransferase

The study investigated the sulfation of minoxidil by liver sulfotransferase in rats. The researchers found that the enzyme activity was specific to certain substrates, and that minoxidil sulfate had direct vasodilator activity when administered to dogs and rats. The study concluded that the enzyme-catalyzed sulfation of N-oxides extends the spectrum of sulfotransferase activities, and provides an additional direction for future studies on the disposition of xenobiotics.