Sulfation of minoxidil by liver sulfotransferase

    September 1982 in “Biochemical Pharmacology
    Garland A. Johnson, Barsuhn Karen, John McCall
    Image of study
    TLDR Liver enzyme helps minoxidil work better for blood vessel relaxation.
    The study investigated the sulfation of minoxidil by liver sulfotransferase in rats. The researchers found that the enzyme activity was specific to certain substrates, and that minoxidil sulfate had direct vasodilator activity when administered to dogs and rats. The study concluded that the enzyme-catalyzed sulfation of N-oxides extends the spectrum of sulfotransferase activities, and provides an additional direction for future studies on the disposition of xenobiotics.
    View this study on →

    Cited in this study