Pharmacokinetic Studies of Minoxidil

    May 1972 in “ Clinical Pharmacology & Therapeutics ”
    Thomas Gottlieb, Richard F. Thomas, Charles A. Chidsey
    Image of study
    TLDR Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.
    This document summarizes two studies on the pharmacokinetics of minoxidil, a new antihypertensive drug, in hypertensive patients. The studies found that minoxidil was rapidly removed from plasma with a half-life of 4.2 hours and was excreted predominantly in the urine as metabolites. The glucuronide conjugate was the predominant metabolite in the urine in the earlier collection periods, whereas the other metabolites of minoxidil were predominant in later periods. The studies suggest a dissociation between the drug in circulating blood and its pharmacologic activity, and that the prolonged hypotensive response to the drug may reflect the fate of the drug at tissue receptor sites.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 1 year ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 4 months ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community Insane dutasteride shed 4 months after switching.

      in Finasteride/Dutasteride  115 upvotes 1 year ago
      The post and conversation are about a user's experience with hair loss treatments, specifically switching from finasteride to dutasteride. The user experienced significant hair shedding after the switch, with others suggesting patience, noting similar experiences, or questioning the user's decision and medical consultation.

      community Reql minoxidil vs fake minoxidil (right)

      in Minoxidil  239 upvotes 5 days ago
      Counterfeit minoxidil is a concern, with users suggesting buying from reputable sources like Costco to ensure authenticity. A bleach test can help verify genuine minoxidil.

    Similar Research

    5 / 1000+ results
      Agent: Minoxidil

      research Agent: Minoxidil

      January 2018 in “Elsevier eBooks”
      Minoxidil helps lower severe blood pressure and promotes hair growth but can have serious side effects and must be used continuously.
      Androgen Antagonists in Androgen Target Tissues

      research Androgen Antagonists in Androgen Target Tissues

      27 citations, January 1984 in “Pharmacology & Therapeutics”
      Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.
      Chapter 14: Principles of Drug Metabolism

      research Chapter 14: Principles of Drug Metabolism

      2 citations, January 1997 in “Principles of Medical Biology”
      Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.