Androgen Antagonists in Androgen Target Tissues

January 1984 in “ Pharmacology & Therapeutics ”

Donald J. Tindall, Ching H. Chang, Thomas J. Lobl, Glenn R. Cunningham

antiandrogens androgen receptors steroid binding pharmacokinetics metabolism acne hirsutism prostate cancer

TLDR Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

The 1984 document reviews the chemistry, mechanisms, and clinical applications of antiandrogens, which inhibit the growth of male accessory sex organs by either directly interacting with androgen receptors or through nonreceptor mediated actions. It discusses the purification and characterization of androgen receptors from animal tissues and the specificity of steroid binding to these receptors. The paper also examines the pharmacokinetics and metabolism of various androgen antagonists, their effects on conditions like acne, hirsutism, and prostate cancer, and the side effects associated with their use. The document concludes that while antiandrogens show significant biological effects, further research is needed to fully understand their mechanisms and to assess their effectiveness and side effects compared to other therapies. The research was supported by NIH grants and involved contributions from several individuals.

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Research cited in this study

8 / 8 results

research Treatment of Hirsutism with Spironolactone

21 citations, March 1982 in “JAMA”

Spironolactone is effective and safe for treating excessive facial hair in women.

research A Novel Use of Spironolactone: Treatment of Hirsutism

124 citations, September 1980 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Spironolactone is effective in treating excessive hair growth in women.

research New Therapeutic Approach to the Hirsute Patient

60 citations, September 1979 in “Fertility and sterility”

Spironolactone can reduce hair growth in women with hirsutism.

research Anti-Androgenicity of Flutamide and Its Metabolite SCH 16423

72 citations, June 1979 in “Biochemical Society Transactions”

Flutamide and its metabolite can effectively reduce androgen effects.

research Pharmacology and Potential Use of Cyproterone Acetate

129 citations, January 1977 in “Hormone and metabolic research”

Cyproterone Acetate effectively treats androgen-related conditions and is used in prostate cancer therapy and hormone therapy for transgender women.

research Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate

59 citations, January 1976 in “Vitamins and hormones”

Prostate cells have proteins that bind to specific hormones, which can increase protein production when activated by these hormones.

research Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism

232 citations, June 1975 in “Journal of Steroid Biochemistry”

Cyproterone acetate is effective for acne but less so for hirsutism and alopecia, with some side effects and quick menstrual cycle recovery after treatment.

research The Antiandrogenic Action of 4-Androsten-3-One-17β-Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ

87 citations, April 1973 in “Endocrinology”

The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

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community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 10 months ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community I find it funny a bunch of us on here are on drugs for hairloss and maintain clean/healthy lives and then there’s these mf’s in the 90’s juiced to the gills with steroids and have better hair than all of us lol

in Satire 353 upvotes 1 year ago

The conversation is about the effects of steroids on hair loss. Some users believe that steroids can cause hair loss, while others argue that it depends on individual sensitivity to DHT. There is also discussion about the appearance of balding individuals who use steroids.

community Is this broscience? From More Plates, More Dates

in Research/Science 22 upvotes 8 months ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Testosterone is 1600, would taking low dose anti-androgens be a viable treatment option for people who’s T spikes on DHT-blockers?

in Treatment 46 upvotes 1 year ago

The post and conversation are about the user's high testosterone levels and their worsening hair loss despite trying various treatments. They are considering using low doses of anti-androgens to lower their testosterone levels as a potential solution.

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research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

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Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition

research Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition

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