Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

    Quan Dong Nguyen, Tao Chen, Xuesheng Wang, Ying Chen, Paul Chien
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    TLDR Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.
    This 1995 study investigated the potential of finasteride in treating androgen-related skin disorders. The researchers found that finasteride inhibits the conversion of testosterone to dihydrotestosterone in human dermal fibroblasts, suggesting its therapeutic potential in treating skin disorders influenced by the action of dihydrotestosterone, such as acne and baldness of the scalp or hirsutism. The study also discussed the different forms of human 5α-reductase isozyme and their tissue distribution in humans. The study confirms the potential therapeutic application of finasteride in androgen-related skin diseases.
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